In vivo nanoparticle delivery general model

Τhe model is based on the work:
Jamie L.Y. Wu, Benjamin P. Stordy, Luan N.M. Nguyen, Christopher P. Deutschman, Warren C.W. Chan. (2022). A proposed mathematical description of in vivo nanoparticle delivery. Advanced Drug Delivery Reviews, 189, 114520 [Link]

Short description of the in vivo nanoparticle delivery

The model uses a compartment framework to describe and quantify the transport and delivery efficiency of nanoparticles in biological systems. The compartments include the administration site, target cell vicinity, target cell interior, off-target sites and excreta. Biological processes that distribute nanoparticles between these compartments are expressed as rate constants. The model also takes into account the nanoparticle biodegradation rate in each compartment. The rate equations that define the compartmental kinetics model are presented below.

*This project has received funding from the European Union EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions under grant agreement nº 101008099